Amebazole – Anti-Protozoal Drug

Composition: Each tablet contains: Secnidazole 1 gm.

Properties and Mechanism of Action: Amebazole contains Secnidazole which belongs to Nitroimidazole derivatives. It is an antiprotozoal drug which has pharmacological activity against Intestinal and Hepatic Amebiasis, Giardiasis and Trichomonas vaginalis. Recent studies showed that a single 1 gm oral dose of Secnidazole is effective to cure bacterial vaginosis associated with Gardnerella vaginalis. 

Indications and Usage

Amebazole is indicated for the treatment of:

  • Intestinal Amebiasis. 
  • Hepatic Amebiasis. 
  • Giardiasis.
  • Urethritis and vaginitis due to Trichomonas vaginals. 

Contraindications

Amebazole is contraindicated in:

  • Patients with known hypersensitivity to imidazole derivatives.
  • Pregnancy and Lactation.

Side Effects

Digestive disorders with abdominal pain, change in taste, glossitis, stomatitis.

Urticaria, moderate leukopenia, reversible upon withdrawal of treatment. 

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Drug-Drug Interactions

Alcoholic drinks and alcohol containing medicines should be avoided during Secnidazole treatment.

Precautions

Do not administer to patients with a history of blood dyscrasias. 

Dosage and Administration

Acute Intestinal Amebiasis: One-day treatment 

  • Adults: 2 gm (2 tablets) as a single dose. 
  • Children: 30 mg/ kg as a single or several divided doses. 

Hepatic Amebiasis: Five-day treatment 

  • Daily dose: Adults: 1.5 gm (one and a half tablets) as a single dose.
  • Children: 30 mg/ kg as a single or several divided doses. 

Urogenital Trichomoniasis: 2 gm (2 tablets) as a single dose.

The dose preferably be taken during a meal.

For Arabic Information
Amebazole- Arabic Information

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