Avocin 1% Topical Clindamycin Solution


Avocin 1% Topical Solution contains Clindamycin Phosphate at concentration equivalent to 10 mg Clindamycin per 1 ml in alcohol and water solution.


Clindamycin Phosphate equivalent to Clindamycin 10 mg per 1 ml solution (1%).


Avocin 1% Topical Solution is indicated in the treatment of acne vulgaris.


Avocin 1 % Topical Solution is contraindicated in individuals with:

  • History of hypersensitivity to preparations containing Clindamycin or Lincomycin.
  • History of regional enteritis or ulcerative colitis.
  • History of antibiotic-associated colitis. 
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Clindamycin Phosphate is inactive and should be converted to the active Clindamycin. This happens by phosphatases on the skin which hydrolyzes Clindamycin Phosphate to Clindamycin. 

Active clindamycin has been shown to have in vitro activity against isolates of Propionibacterium acnes. This may account for and explain its usefulness in treatment of acne.

Clindamycin activity has been demonstrated in comedonal extracts from acne patients. The mean concentration of antibiotic activity in comedonal extracts was 1.4 mcg/ml. 

Clindamycin in Vitro inhibits all Propionibacterium acnes cultures tested (MIC 0.4 mcg/ml). 

Free fatty acids on the skin surface have been decreased from approximately 14% to 2% following application of topical Clindamycin. 


  • For topical use only.
  • Avocin 1% Topical Solution contains an Isopropyl Alcohol base, so avoid the contact with eyes as it will cause burning and irritation. In case of accidental contact with eyes, abraded skin or mucous membranes, wash with copious  amounts of cold tap water. 
  • The solution has unpleasant taste and caution should be considered when applying around the mouth.
  • Avocin 1% Topical Solution should be prescribed with caution in atopic individuals.


Diarrhea, bloody diarrhea, non-specific colitis and pseudomembranous colitis (antibiotic associated colitis) have been reported with many antibiotics used systematically including Clindamycin. No serious diarrhea or pseudomembranous colitis occurred in controlled clinical trials with Clindamycin phosphate topical solution.However. it is theoretically possible that Clindamycin could be present systemically through absorption from the skin surface.

When it is applied topically , the physician should be alert to the remote possibility of an antibiotic induced severe  diarrhea or colitis.

If significant diarrhea occurs during therapy, the drug should be discontinued. significant diarrhea (which theoretically may occur up to several weeks post therapy) should be managed as if antibiotic associated.

Studies indicate a toxin(s) produced by Clostridia (especially Clostridium Difficile) is the principal direct cause of antibiotic-associated colitis. 

Direction of use

Apply a thin film of Avocin 1% Topical Solution twice daily to the affected area. 

Pregnancy and Lactation

Safety for use of Clindamycin Phosphate topical solution in pregnancy has not been established. It is not known whether Clindamycin is excreted in human milk following the use of Avocin 1% Topical Solution. However, orally and parenterally administered Clindamycin has been reported to appear in breast milk. As a general rule, nursing should not be undertaken while a patient is on a drug since many drugs are excreted in human milk.

Side effects

The most commonly reported medical events were: skin dryness, irritation, stinging and erythema. (believed to be caused by the Alcohol vehicle). Also diarrhea and gastrointestinal reactions were reported. Rarely reported adverse effects include: headache, urinary frequency, contact dermatitis and oily skin.


Store at room temperature ( 15°- 30°C ).

Patient Information Leaflet

ENG - Patient Information Leaflet
Avocin 1% Topical Solution – Patient Information Leaflet
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Categories and tags: D10AF01, Clindamycin, Antiinfectives for treatment of acne, ANTI-ACNE PREPARATIONS FOR TOPICAL USE, ANTI-ACNE PREPARATIONS, DERMATOLOGICALS MEDICINES.

Avocin Topical Solution- Arabic Information

For Arabic Information
Avocin Topical Soln- Arabic Information

Possible Alternatives

English Alternatives
Avocin- Alternatives

ADCOCLINDACE, CLINACYN-T, CLINCIN 1%, CLINDACIN-T, CLINDASOL, Derma-T, Edason 1% Topical Clindamycin Solution, CLINDACIN 1%, DALACIN-T, KLENDABIOTICAM 1%., Avocin 1% Topical Clindamycin Solution.

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