Clarixin (Clarithromycin) – Broad Spectrum Antibiotic

Clarixin is indicated for: Treatment of infections caused by microorganisms sensitive to Clarixin such as:

  • Infections of nasopharyngeal tract (tonsillitis, pharyngitis) and paranasal sinusitis.
  • Lower respiratory tract infections: bronchitis, bacterial pneumonia and atypical pneumonia.
  • Skin infections: impetigo, erysipelas, folliculitis, furunculosis and septic wounds.
  • To eradicate helicobacter pylori in the treatment regimens for peptic ulcer.

Dosage And Administration

Respiratory tract/skin and soft tissue infections Usual adult dose: 250 mg every BD (up to 7 days), this may be increased to 500mg BD up to 14 days in sever infections.

Usual pediatric dose:

  • Children older than 12 years: As for adults.
  • Children younger than 12 years: Use the pediatric suspension.

Eradication of H.pylori in patients with duodenal ulcers

  • Dual therapy:  The usual dose for clarithromycin is 500mg TID for 14 days. Clarixin should be administered with 40mg omeprazole OD.
  • Triples therapy: Clarithromycin 500mg BD with amoxycillin 1000mg BD, and omeprazole 20mg daily for 10 days.

Elderly dose: As for adults.

Renal impairment: Dosage adjustment are not usually required except in patients with severe renal impairment (creatinine clearance 30ml/min). if adjustment is necessary, the total dosage should be reduced by half e.g. 250mg OD or 250mg BD in more severe infections.

Clarixin can be taken without regard to meals.

Pharmacological Informations

Clarixin is a semi-synthetic macrolide antibiotic, it exerts its antibacterial activity by inhibition of protein synthesis through linkage to 50 S ribosomal subunit.

Clarixin is active in vitro against the following microorganisms: Streptococcus agalacticae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae, Haemophilus influenzae. Haemophilus parainfluenzae, Neisseria gonorrhea, Listeria monocytogenes, Legionella pneumophila, Mycoplasma pneumoniae, Campylobacter pylori, Campylobacter jejuni, Chlamydia trachomatis, Branhamella catarrhalis, Bordetella pertussis, Staphylococcus aureus, Propionibacterium acnes & Helicobacter pylori.

Side Effects

Clarithromycin is generally well tolerated. Side effects include nausea, vomiting, diarrhea, and abdominal pain, stomatitis, glossitis, and oral monilia.

Other side effects include headache and allergic reactions ranging from urticaria and mild skin eruptions to anaphylaxis and rarely Steven-Johnson syndrome. Taste perversion may occur. Reversible tongue discoloration has been seen in clinical trials when Clarithromycin and omeprazole were given together. There have been reports of transient central nervous system side effects including: anxiety, hallucinations, psychosis, bad dreams, and confusion. Pseudomembranous colitis has been reported rarely.


Prolonged or repeated use of clarithromycin may result in an overgrowth of non susceptible bacteria or fungi (in such a case the therapy should be stopped).

Particular caution should be taken when administering the drug to elderly patients (above 65 years old) or patients with impaired liver function.

Drug Interactions

Clarithromycin has been shown not to interact with oral contraceptives.

Clarithromycin may increase carbamazepine plasma levels significantly thus patients under such combination must be monitored carefully.

As with other macrolides, the use of clarithromycin in patients concurrently taking drugs metabolized by the cytochrome P450 system) e.g.: warfarin, ergot alkaloids, triazolam, midazolam, disopyramide, lovastatin, phenytoin and cyclosporine, may be associated with elevations in serum levels of these drugs.

Co-adminisration with theophylline may increase the plasma level of theophylline but not to a significant extent that need dosage adjustment.

Concurrent use of clarithromycin and pimozide should be avoided. Concurrent administration with zidovudine to HIV infected adults may result in decreased steady state zidovudine levels. No such reaction has been reported in children.

Ranitidine and Aluminum containing Anti-acids: increased plasma levels of clarithromycin may occur when clarithromycin is co-adminstered.

Digoxin: concomitant use with clarithromycin should be avoided.


Patients with known hypersensitivity to macrolides, pregnancy, breast feeding and severe liver insufficiency.

Over dosage

In case of clarithromycin overdosage, gastric lavage and supportive measures are indicated. Clarithromycin serum levels are not expected to be affected by hemodialysis or peritoneal dialysis.

other information

Storage conditions

Store below 30°C in dry place.


  • Clarixin 250mg F/C tablet: Clarithromycin 250mg/tablet. (Available in different pack sizes)
  • Clarixin 500mg F/C tablet: Clarithromycin 500mg/tablet. (Available in different pack sizes)


A drug is a product which acts on your health and its consumption could be dangerous when you do not follow the instructions. Follow strictly the doctor’s prescriptions, the method of use and the instructions of the pharmacist who sold the medicament.

The doctor and the pharmacist know the medicine, its benefits and risks. Do not by yourself interrupt the period of treatment prescribed for you. Do not repeat the same prescription without consulting your doctor. Keep out of the reach of children.

كلاريكسين اقراص CLARIXINE TABLET
كلاريكسين اقراص CLARIXINE TABLET


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