Cymbalta increases the levels of serotonin and noradrenaline in the nervous system. Cymbalta is used to treat:

  • depression
  • generalised anxiety disorder (chronic feeling of anxiety or nervousness)
  • diabetic neuropathic pain (often described as burning, stabbing, stinging, shooting or aching or like an electric shock. There may be loss of feeling in the affected area, or sensations such as touch, heat, cold or pressure may cause pain)

Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed it for another reason.

CYMBALTA is not recommended for use in children and adolescents under the age of 18 years.

Your doctor may continue to give you Cymbalta when you are feeling better to prevent your depression or anxiety from returning.


Always take Cymbalta exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Cymbalta starts to work in most people with depression or anxiety within two weeks of starting treatment. Cymbalta starts to work in most people with diabetic neuropathic pain within 1 week of starting treatment.

For depression and diabetic neuropathic pain: The usual dose of Cymbalta is one capsule (60 mg duloxetine) once a day, but your doctor will prescribe the dose that is right for you.

For generalised anxiety disorder: The usual starting dose of Cymbalta is 30 mg once a day after which most patients will receive 60 mg once a day, but your doctor will prescribe the dose that is right for you. The dose may be adjusted up to 120 mg once daily based on your response to Cymbalta.

Cymbalta is for oral use. You should swallow your capsule whole with a drink of water.

Do not open the capsules and crush the pellets inside because the medicine may not work as well.

To help you remember to take Cymbalta, you may find it easier to take it at the same times every day.

Talk with your doctor about how long you should keep taking Cymbalta. Do not stop taking Cymbalta without talking to your doctor.

If you take more Cymbalta than you should

Call your doctor or pharmacist immediately if you take more than the amount of Cymbalta prescribed by your doctor. Symptoms of overdose include sleepiness, coma, serotonin syndrome (a rare reaction which may cause feelings of great happiness, drowsiness, clumsiness, restlessness, feeling of being drunk, fever, sweating or rigid muscles), fits, vomiting and fast heart rate.

If you forget to take Cymbalta

If you miss a dose, take it as soon as you remember. However, if it is time for your next dose, skip the missed dose and take only a single dose as usual. Do not take a double dose to make up for a forgotten dose. Do not take more than the daily amount of Cymbalta that has been prescribed for you in one day.

If you stop taking Cymbalta

DO NOT stop taking your capsules without the advice of your doctor even if you feel better. If your doctor thinks that you no longer need Cymbalta he or she will ask you to reduce your dose over at least 2 weeks before stopping treatment altogether.

Some patients who stop taking Cymbalta suddenly have had symptoms such as: dizziness, fatigue, tingling feelings like pins and needles, sleep disturbances (vivid dreams, nightmares, inability to sleep), feeling restless or agitated, feeling anxious, feeling sick (nausea) or being sick (vomiting), tremor (shakiness), headaches, feeling irritable, diarrhoea, excessive sweating or vertigo.

These symptoms are usually not serious and disappear within a few days, but if you have symptoms that are troublesome you should ask your doctor for advice.

If you have further questions on the use of this product, ask your doctor or pharmacist.


Like all medicines, Cymbalta can cause side effects, although not everybody gets them. These effects are normally mild to moderate and often disappear after a few weeks.
Do not be alarmed by the following lists of side effects. You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Very common side effects (affects more than 1 user in 10) : feeling sick (nausea), headache, dry mouth feeling sleepy and dizziness.

Common side effects (affects 1 to 10 users in 100): ⚫ fatigue, anxiety, feeling agitated or having abnormal dreams, ⚫ tremor or numbness, including numbness or tingling of the skin, ⚫diarrhoea, constipation, being sick (vomiting), heartburn, breaking wind, stomach pain, ⚫ tinnitus (perception of sound in the ear when there is no external sound), ⚫ blurred eyesight, ⚫ feeling the heart pumping in the chest, flushing, increased sweating, ⚫ problems getting an erection, less sex drive and abnormal orgasm, ⚫ (itchy) rash, ⚫ muscle pain, muscle tightness, muscle spasm, ⚫ increased yawning, ⚫ lack of appetite, weight loss

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