Urosolvine Effervescent Granules For management of urolithiasis and gouty arthritis


Each 5 g (sachet) contains:

  • Piperazine Citrate 0.1408 g (Eq. To 0.128 g.Piperazine Hydrate)
  • Colchicine Crystals 0.3 mg
  • Atropine Sulphate 0.128 mg

Inactive Ingredients: Sed.Bicarbonate, Citric acid anhy., Tartaric acid, P.V.P, Lemon oil, Sucrose.

  • Pharmaceutical form: Effervescent Granules
  • Pharmacotherapeutic group: Uricosuric

Pharmacological action

An acute attack of gout apparently occurs as a result of increasing uric acid concentration that results in deposition of monosodium urate in the joint tissue. Piperazine known for many years to be an active drug in the treatment of gout and urinary lithiasis. increase the solubility of urates in the urine. It is relatively non-toxic.

Colchicine gives rapid relief from pain in acute attacks of gout and the drug is specific for this condition to the extent that it can be used as a diagnostic agent in gout and gouty arthritis. Colchicine possesses anti-inflammatory properties. Although it is highly effective in treating acute gouty arthritis, it is not effective for other types of pain. It is not of neutrophils.

an analgesic and does not affect uric acid clearance. Instead,colchicine binds to proteins in microtubules This binding,in turn, inhibits the migration of neutrophils into the area of inflammation, thereby interfering with the inflammatory response to urate crystal deposition. Atropine sulphate is added to relieve the spasm of the urinary tract.


Urosolvine contains a typical uricosuric agent that promotes the urinary excretion of uric acid and thereby lower -Sodium citrate is an alkalinising agent since the citrate is converted into bicarbonate, alkaline urine is definitely more serum uric acid concentration suitable for the excretion of urates in a more soluble form.


  • Acute and chronic gout
  • Gouty arthritis
  • For prophylaxis against urinary lithiasis (urate stones).

Dosage and administration

  •  In acute attack: one sachet dissolved in a half glass of water 6 times daily.
  • To prevent acute attack: 2 sachets dissolved in a glass of water 2 times daily.
  • As a prophylaxis: 2 sachets dissolved in a glass of water once daily.


  • Known hypersensitivity to any of the components of the drug.
  • Blood dyscrasias
  • Acute dehydration,anuria or hyperkalemia

Side effects

Occasionally nausea, vomiting,abdominal pain and diarrhea may occur.

Drug interactions


Pregnancy and lactation

  • Contraindicated in pregnant women.
  • It is unknown if drug appears in breast milk.

Precautions and warnings

  • Used with caution in patients with serious GIT, renal, hepatic, and cardiovascular disorders.
  • It should not be used in children, geriatrics, debilitated patients and nursing women.
يوروسولفين أكياس فوارة ..نشرة تعليمات المريض
يوروسولفين أكياس فوارة ..نشرة تعليمات المريض

Urosolvine Effervescent Granules – Patient Information Leaflet

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